HD-PTP/PTPN23 hypomorphic mice display lipodystrophy

Brian A. Davies, Johanna A. Payne, Cole P. Martin, Destiny Schultz, Bennett G. Childs, Cheng Zhang, Karthik Jeganathan, Ines Sturmlechner, Thomas A. White, Alain de Bruin, Huiqin Chen, Michael A. Davies, Sarah Jachim, Nathan K. LeBrasseur, Robert C. Piper, Hu Li, Darren J. Baker, Jan van Deursen, David J. Katzmann  bioRxiv 2022.08.02.502401; doi: https://doi.org/10.1101/2022.08.02.502401

 

PMP22 associates with MPZ via their transmembrane domains and disrupting this interaction causes a loss-of-function phenotype similar to hereditary neuropathy associated with liability to pressure palsies (HNPP).

Pashkova N, Peterson TA, Ptak CP, Winistorfer SC, Ahern CA, Shy ME, Piper RC.

bioRxiv [Preprint]. 2023 Dec 24:2023.12.24.573255. doi: 10.1101/2023.12.24.573255.

PMID: 38187781 Free PMC article. Preprint.

 

Beta-subunit-eliminated eHAP expression (BeHAPe) cells reveal subunit regulation of the cardiac voltage-gated sodium channel.

Minard AY, Clark CJ, Ahern CA, Piper RC.

J Biol Chem. 2023 Sep;299(9):105132. doi: 10.1016/j.jbc.2023.105132. Epub 2023 Aug 6.

PMID: 37544648 Free PMC article.

 

Homomeric interactions of the MPZ Ig domain and their relation to Charcot-Marie-Tooth disease.

Ptak CP, Peterson TA, Hopkins JB, Ahern CA, Shy ME, Piper RC.

Brain. 2023 Dec 1;146(12):5110-5123. doi: 10.1093/brain/awad258.

PMID: 37542466

 

Dynein-Mediated Trafficking: A New Mechanism of Diabetic Podocytopathy.

Sun H, Weidner J, Allamargot C, Piper RC, Misurac J, Nester C.

Kidney360. 2023 Feb 1;4(2):162-176. doi: 10.34067/KID.0006852022. Epub 2022 Dec 6.

PMID: 36821608 Free PMC article.

 

Bro1 family proteins harmonize cargo sorting with vesicle formation.

Tseng CC, Piper RC, Katzmann DJ.

Bioessays. 2022 Aug;44(8):e2100276. doi: 10.1002/bies.202100276. Epub 2022 Jun 30.

PMID: 35770783 Free PMC article.

 

Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer's disease risk factor CALM bidirectionally controls synaptic plasticity.

Azarnia Tehran D, Kochlamazashvili G, Pampaloni NP, Sposini S, Shergill JK, Lehmann M, Pashkova N, Schmidt C, Löwe D, Napieczynska H, Heuser A, Plested AJR, Perrais D, Piper RC, Haucke V, Maritzen T.

Sci Adv. 2022 May 27;8(21):eabl5032. doi: 10.1126/sciadv.abl5032. Epub 2022 May 25.

PMID: 35613266 Free PMC article.

 

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.

Pashkova N, Gakhar L, Yu L, Schnicker NJ, Minard AY, Winistorfer S, Johnson IE, Piper RC.

Elife. 2021 Nov 25;10:e72583. doi: 10.7554/eLife.72583.

PMID: 34821552 Free PMC article.

 

Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase.

Pashkova N, Yu L, Schnicker NJ, Tseng CC, Gakhar L, Katzmann DJ, Piper RC.

Mol Biol Cell. 2021 Dec 1;32(22):ar42. doi: 10.1091/mbc.E21-04-0219. Epub 2021 Sep 29.

PMID: 34586919 Free PMC article.

 

Deconvolution of Multiple Rab Binding Domains Using the Batch Yeast 2-Hybrid Method DEEPN.

Peterson TA, Piper RC.

Methods Mol Biol. 2021;2293:117-141. doi: 10.1007/978-1-0716-1346-7_9.

PMID: 34453714 Free PMC article.

 

Bro1 stimulates Vps4 to promote intralumenal vesicle formation during multivesicular body biogenesis.

Tseng CC, Dean S, Davies BA, Azmi IF, Pashkova N, Payne JA, Staffenhagen J, West M, Piper RC, Odorizzi G, Katzmann DJ.

J Cell Biol. 2021 Aug 2;220(8):e202102070. doi: 10.1083/jcb.202102070. Epub 2021 Jun 23.

PMID: 34160559 Free PMC article.

 

ESCRTs cut some slack.

Piper RC.

Nat Cell Biol. 2020 Aug;22(8):915-916. doi: 10.1038/s41556-020-0557-1.

PMID: 32753668 Free PMC article. No abstract available.

 

A Cycle of Ubiquitination Regulates Adaptor Function of the Nedd4-Family Ubiquitin Ligase Rsp5.

MacDonald C, Shields SB, Williams CA, Winistorfer S, Piper RC.

Curr Biol. 2020 Feb 3;30(3):465-479.e5. doi: 10.1016/j.cub.2019.11.086. Epub 2020 Jan 16.

PMID: 31956026 Free PMC article.

 

Synaptotagmin 17 controls neurite outgrowth and synaptic physiology via distinct cellular pathways.

Ruhl DA, Bomba-Warczak E, Watson ET, Bradberry MM, Peterson TA, Basu T, Frelka A, Evans CS, Briguglio JS, Basta T, Stowell MHB, Savas JN, Roopra A, Pearce RA, Piper RC, Chapman ER.

Nat Commun. 2019 Aug 6;10(1):3532. doi: 10.1038/s41467-019-11459-4.

PMID: 31387992 Free PMC article.

 

MALTA: a calculator for estimating the coverage with shRNA, CRISPR, and cDNA libraries.

Krishnamani V, Stamnes MA, Piper RC.

SoftwareX. 2019 Jan-Jun;9:154-160. doi: 10.1016/j.softx.2019.01.006. Epub 2019 Feb 14.

PMID: 31304228 Free PMC article.

 

Informatic Analysis of Sequence Data from Batch Yeast 2-Hybrid Screens.

Krishnamani V, Peterson TA, Piper RC, Stamnes MA.

J Vis Exp. 2018 Jun 28;(136):57802. doi: 10.3791/57802.

PMID: 30010636 Free PMC article.

 

A Yeast 2-Hybrid Screen in Batch to Compare Protein Interactions.

Peterson TA, Stamnes MA, Piper RC.

J Vis Exp. 2018 Jun 6;(136):57801. doi: 10.3791/57801.

PMID: 29939176 Free PMC article.

 

Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates β-Cell Mitophagy.

Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA.

Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27.

PMID: 29180353 Free PMC article.

 

COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal.

Xu P, Hankins HM, MacDonald C, Erlinger SJ, Frazier MN, Diab NS, Piper RC, Jackson LP, MacGurn JA, Graham TR.

Elife. 2017 Oct 23;6:e28342. doi: 10.7554/eLife.28342.

PMID: 29058666 Free PMC article.

 

Genetic dissection of early endosomal recycling highlights a TORC1-independent role for Rag GTPases.

MacDonald C, Piper RC.

J Cell Biol. 2017 Oct 2;216(10):3275-3290. doi: 10.1083/jcb.201702177. Epub 2017 Aug 2.

PMID: 28768685 Free PMC article.

 

Enzyme reversal to explore the function of yeast E3 ubiquitin-ligases.

MacDonald C, Winistorfer S, Pope RM, Wright ME, Piper RC.

Traffic. 2017 Jul;18(7):465-484. doi: 10.1111/tra.12485. Epub 2017 Jun 1.

PMID: 28382714 Free PMC article.

 

DEEPN as an Approach for Batch Processing of Yeast 2-Hybrid Interactions.

Pashkova N, Peterson TA, Krishnamani V, Breheny P, Stamnes M, Piper RC.

Cell Rep. 2016 Sep 27;17(1):303-315. doi: 10.1016/j.celrep.2016.08.095.

PMID: 27681439 Free PMC article.

 

Cell surface recycling in yeast: mechanisms and machineries.

MacDonald C, Piper RC.

Biochem Soc Trans. 2016 Apr 15;44(2):474-8. doi: 10.1042/BST20150263.

PMID: 27068957 Free PMC article. Review.

 

Tetraspan cargo adaptors usher GPI-anchored proteins into multivesicular bodies.

MacDonald C, Stamnes MA, Katzmann DJ, Piper RC.

Cell Cycle. 2015;14(23):3673-8. doi: 10.1080/15384101.2015.1100773.

PMID: 26505929 Free PMC article.

 

A family of tetraspans organizes cargo for sorting into multivesicular bodies.

MacDonald C, Payne JA, Aboian M, Smith W, Katzmann DJ, Piper RC.

Dev Cell. 2015 May 4;33(3):328-42. doi: 10.1016/j.devcel.2015.03.007.

PMID: 25942624 Free PMC article.

 

Puromycin- and methotrexate-resistance cassettes and optimized Cre-recombinase expression plasmids for use in yeast.

MacDonald C, Piper RC.

Yeast. 2015 May;32(5):423-38. doi: 10.1002/yea.3069. Epub 2015 Mar 19.

PMID: 25688547 Free PMC article.

 

Crystal structure of a complex of NOD1 CARD and ubiquitin.

Ver Heul AM, Gakhar L, Piper RC, Subramanian R.

PLoS One. 2014 Aug 15;9(8):e104017. doi: 10.1371/journal.pone.0104017. eCollection 2014.

PMID: 25127239 Free PMC article.

 

Ubiquitin-dependent sorting in endocytosis.

Piper RC, Dikic I, Lukacs GL.

Cold Spring Harb Perspect Biol. 2014 Jan 1;6(1):a016808. doi: 10.1101/cshperspect.a016808.

PMID: 24384571 Free PMC article. Review.

 

Backbone and side-chain NMR assignments for the C-terminal domain of mammalian Vps28.

Peterson TA, Yu L, Piper RC.

Biomol NMR Assign. 2015 Apr;9(1):21-4. doi: 10.1007/s12104-013-9537-8. Epub 2013 Dec 24.

PMID: 24366722 Free PMC article.

 

Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding.

Sette P, Nagashima K, Piper RC, Bouamr F.

Retrovirology. 2013 Jul 29;10:79. doi: 10.1186/1742-4690-10-79.

PMID: 23895345 Free PMC article.

 

The yeast Alix homolog Bro1 functions as a ubiquitin receptor for protein sorting into multivesicular endosomes.

Pashkova N, Gakhar L, Winistorfer SC, Sunshine AB, Rich M, Dunham MJ, Yu L, Piper RC.

Dev Cell. 2013 Jun 10;25(5):520-33. doi: 10.1016/j.devcel.2013.04.007. Epub 2013 May 30.

PMID: 23726974 Free PMC article.

 

Ubiquitin regulates caspase recruitment domain-mediated signaling by nucleotide-binding oligomerization domain-containing proteins NOD1 and NOD2.

Ver Heul AM, Fowler CA, Ramaswamy S, Piper RC.

J Biol Chem. 2013 Mar 8;288(10):6890-902. doi: 10.1074/jbc.M112.413781. Epub 2013 Jan 8.

PMID: 23300079 Free PMC article.

 

A set of dual promoter vectors for high throughput cloning, screening, and protein expression in eukaryotic and prokaryotic systems from a single plasmid.

Sinah N, Williams CA, Piper RC, Shields SB.

BMC Biotechnol. 2012 Aug 23;12:54. doi: 10.1186/1472-6750-12-54.

PMID: 22916790 Free PMC article.

 

UBAP1: a new ESCRT member joins the cl_Ub.

Pashkova N, Piper RC.

Structure. 2012 Mar 7;20(3):383-5. doi: 10.1016/j.str.2012.02.004.

PMID: 22404994 Free PMC article.

 

Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation.

MacDonald C, Buchkovich NJ, Stringer DK, Emr SD, Piper RC.

EMBO Rep. 2012 Apr;13(4):331-8. doi: 10.1038/embor.2012.18.

PMID: 22370727 Free PMC article.

 

Sna3 is an Rsp5 adaptor protein that relies on ubiquitination for its MVB sorting.

MacDonald C, Stringer DK, Piper RC.

Traffic. 2012 Apr;13(4):586-98. doi: 10.1111/j.1600-0854.2011.01326.x. Epub 2012 Jan 31.

PMID: 22212814 Free PMC article.

 

Endosomal transport via ubiquitination.

Piper RC, Lehner PJ.

Trends Cell Biol. 2011 Nov;21(11):647-55. doi: 10.1016/j.tcb.2011.08.007. Epub 2011 Sep 28.

PMID: 21955996 Free PMC article. Review.

 

Terminating protein ubiquitination: Hasta la vista, ubiquitin.

Stringer DK, Piper RC.

Cell Cycle. 2011 Sep 15;10(18):3067-71. doi: 10.4161/cc.10.18.17191. Epub 2011 Sep 15.

PMID: 21926471 Free PMC article.

 

Opportunities for improving pLDH-based malaria diagnostic tests.

Piper RC, Buchanan I, Choi YH, Makler MT.

Malar J. 2011 Aug 1;10:213. doi: 10.1186/1475-2875-10-213.

PMID: 21806821 Free PMC article.

 

How ubiquitin functions with ESCRTs.

Shields SB, Piper RC.

Traffic. 2011 Oct;12(10):1306-17. doi: 10.1111/j.1600-0854.2011.01242.x. Epub 2011 Jul 27.

PMID: 21722280 Free PMC article. Review.

 

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination.

Stringer DK, Piper RC.

J Cell Biol. 2011 Jan 24;192(2):229-42. doi: 10.1083/jcb.201008121. Epub 2011 Jan 17.

PMID: 21242292 Free PMC article.

 

WD40 repeat propellers define a ubiquitin-binding domain that regulates turnover of F box proteins.

Pashkova N, Gakhar L, Winistorfer SC, Yu L, Ramaswamy S, Piper RC.

Mol Cell. 2010 Nov 12;40(3):433-43. doi: 10.1016/j.molcel.2010.10.018.

PMID: 21070969 Free PMC article.

 

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.

Zhou R, Kabra R, Olson DR, Piper RC, Snyder PM.

J Biol Chem. 2010 Oct 1;285(40):30523-30. doi: 10.1074/jbc.M110.150755. Epub 2010 Jul 30.

PMID: 20675381 Free PMC article.

 

Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex.

Kamadurai HB, Souphron J, Scott DC, Duda DM, Miller DJ, Stringer D, Piper RC, Schulman BA.

Mol Cell. 2009 Dec 25;36(6):1095-102. doi: 10.1016/j.molcel.2009.11.010.

PMID: 20064473 Free PMC article.

 

Rapid malaria tests: where do we go after 20 years?

Makler MT, Piper RC.

Am J Trop Med Hyg. 2009 Dec;81(6):921-6. doi: 10.4269/ajtmh.2009.09-0202.

PMID: 19996417

 

Use of malaria rapid diagnostic test to identify Plasmodium knowlesi infection.

McCutchan TF, Piper RC, Makler MT.

Emerg Infect Dis. 2008 Nov;14(11):1750-2. doi: 10.3201/eid1411.080480.

PMID: 18976561 Free PMC article.

 

DOA1/UFD3 plays a role in sorting ubiquitinated membrane proteins into multivesicular bodies.

Ren J, Pashkova N, Winistorfer S, Piper RC.

J Biol Chem. 2008 Aug 1;283(31):21599-611. doi: 10.1074/jbc.M802982200. Epub 2008 May 28.

PMID: 18508771 Free PMC article.

 

The use of fluorescence microscopy to define polymer localisation to the late endocytic compartments in cells that are targets for drug delivery.

Richardson SC, Wallom KL, Ferguson EL, Deacon SP, Davies MW, Powell AJ, Piper RC, Duncan R.

J Control Release. 2008 Apr 7;127(1):1-11. doi: 10.1016/j.jconrel.2007.12.015. Epub 2008 Jan 4.

PMID: 18281120 Free PMC article.

 

Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.

Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17518-23. doi: 10.1073/pnas.0702275104. Epub 2007 Oct 23.

PMID: 17956977 Free PMC article.

 

Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes.

Piper RC, Luzio JP.

Curr Opin Cell Biol. 2007 Aug;19(4):459-65. doi: 10.1016/j.ceb.2007.07.002. Epub 2007 Aug 3.

PMID: 17689064 Free PMC article. Review.

 

Biogenesis and function of multivesicular bodies.

Piper RC, Katzmann DJ.

Annu Rev Cell Dev Biol. 2007;23:519-47. doi: 10.1146/annurev.cellbio.23.090506.123319.

PMID: 17506697 Free PMC article. Review.

 

Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-bisphosphate on vacuole membranes and vacuolar fusion defects.

Wiradjaja F, Ooms LM, Tahirovic S, Kuhne E, Devenish RJ, Munn AL, Piper RC, Mayinger P, Mitchell CA.

J Biol Chem. 2007 Jun 1;282(22):16295-307. doi: 10.1074/jbc.M701038200. Epub 2007 Mar 28.

PMID: 17392273

 

Epidermal growth factor receptor fate is controlled by Hrs tyrosine phosphorylation sites that regulate Hrs degradation.

Stern KA, Visser Smit GD, Place TL, Winistorfer S, Piper RC, Lill NL.

Mol Cell Biol. 2007 Feb;27(3):888-98. doi: 10.1128/MCB.02356-05. Epub 2006 Nov 13.

PMID: 17101784 Free PMC article.

 

Hse1, a component of the yeast Hrs-STAM ubiquitin-sorting complex, associates with ubiquitin peptidases and a ligase to control sorting efficiency into multivesicular bodies.

Ren J, Kee Y, Huibregtse JM, Piper RC.

Mol Biol Cell. 2007 Jan;18(1):324-35. doi: 10.1091/mbc.e06-06-0557. Epub 2006 Nov 1.

PMID: 17079730 Free PMC article.

 

Lactate dehydrogenase and the diagnosis of malaria.

Makler MT, Piper RC, Milhous WK.

Parasitol Today. 1998 Sep;14(9):376-7. doi: 10.1016/s0169-4758(98)01284-8.

PMID: 17040820

 

Successful transporter gets an EGO boost.

Piper RC.

Dev Cell. 2006 Jul;11(1):6-7. doi: 10.1016/j.devcel.2006.06.008.

PMID: 16824948

 

Membrane traffic to and from lysosomes.

Luzio JP, Pryor PR, Gray SR, Gratian MJ, Piper RC, Bright NA.

Biochem Soc Symp. 2005;(72):77-86. doi: 10.1042/bss0720077.

PMID: 15649132 Review.

 

The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs.

Bilodeau PS, Winistorfer SC, Allaman MM, Surendhran K, Kearney WR, Robertson AD, Piper RC.

J Biol Chem. 2004 Dec 24;279(52):54808-16. doi: 10.1074/jbc.M406654200. Epub 2004 Oct 19.

PMID: 15494413 Free PMC article.

 

CUPpling calcium to lysosomal biogenesis.

Piper RC, Luzio JP.

Trends Cell Biol. 2004 Sep;14(9):471-3. doi: 10.1016/j.tcb.2004.07.010.

PMID: 15350973 Review.

 

Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites.

Brown WM, Yowell CA, Hoard A, Vander Jagt TA, Hunsaker LA, Deck LM, Royer RE, Piper RC, Dame JB, Makler MT, Vander Jagt DL.

Biochemistry. 2004 May 25;43(20):6219-29. doi: 10.1021/bi049892w.

PMID: 15147206

 

Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.

Pryor PR, Mullock BM, Bright NA, Lindsay MR, Gray SR, Richardson SC, Stewart A, James DE, Piper RC, Luzio JP.

EMBO Rep. 2004 Jun;5(6):590-5. doi: 10.1038/sj.embor.7400150. Epub 2004 May 7.

PMID: 15133481 Free PMC article.

 

Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors.

Dove SK, Piper RC, McEwen RK, Yu JW, King MC, Hughes DC, Thuring J, Holmes AB, Cooke FT, Michell RH, Parker PJ, Lemmon MA.

EMBO J. 2004 May 5;23(9):1922-33. doi: 10.1038/sj.emboj.7600203. Epub 2004 Apr 22.

PMID: 15103325 Free PMC article.

 

GGA proteins bind ubiquitin to facilitate sorting at the trans-Golgi network.

Scott PM, Bilodeau PS, Zhdankina O, Winistorfer SC, Hauglund MJ, Allaman MM, Kearney WR, Robertson AD, Boman AL, Piper RC.

Nat Cell Biol. 2004 Mar;6(3):252-9. doi: 10.1038/ncb1107. Epub 2004 Feb 22.

PMID: 15039776

 

Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton.

Richardson SC, Winistorfer SC, Poupon V, Luzio JP, Piper RC.

Mol Biol Cell. 2004 Mar;15(3):1197-210. doi: 10.1091/mbc.e03-06-0358. Epub 2003 Dec 10.

PMID: 14668490 Free PMC article.

 

Vps27-Hse1 and ESCRT-I complexes cooperate to increase efficiency of sorting ubiquitinated proteins at the endosome.

Bilodeau PS, Winistorfer SC, Kearney WR, Robertson AD, Piper RC.

J Cell Biol. 2003 Oct 27;163(2):237-43. doi: 10.1083/jcb.200305007.

PMID: 14581452 Free PMC article.

 

The role of mVps18p in clustering, fusion, and intracellular localization of late endocytic organelles.

Poupon V, Stewart A, Gray SR, Piper RC, Luzio JP.

Mol Biol Cell. 2003 Oct;14(10):4015-27. doi: 10.1091/mbc.e03-01-0040. Epub 2003 Jul 11.

PMID: 14517315 Free PMC article.

 

Vps20p and Vta1p interact with Vps4p and function in multivesicular body sorting and endosomal transport in Saccharomyces cerevisiae.

Yeo SC, Xu L, Ren J, Boulton VJ, Wagle MD, Liu C, Ren G, Wong P, Zahn R, Sasajala P, Yang H, Piper RC, Munn AL.

J Cell Sci. 2003 Oct 1;116(Pt 19):3957-70. doi: 10.1242/jcs.00751.

PMID: 12953057

 

Membrane dynamics and the biogenesis of lysosomes.

Luzio JP, Poupon V, Lindsay MR, Mullock BM, Piper RC, Pryor PR.

Mol Membr Biol. 2003 Apr-Jun;20(2):141-54. doi: 10.1080/0968768031000089546.

PMID: 12851071 Review.

 

The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting.

Bilodeau PS, Urbanowski JL, Winistorfer SC, Piper RC.

Nat Cell Biol. 2002 Jul;4(7):534-9. doi: 10.1038/ncb815.

PMID: 12055639

 

Ubiquitin sorts proteins into the intralumenal degradative compartment of the late-endosome/vacuole.

Urbanowski JL, Piper RC.

Traffic. 2001 Sep;2(9):622-30. doi: 10.1034/j.1600-0854.2001.20905.x.

PMID: 11555416

 

Late endosomes: sorting and partitioning in multivesicular bodies.

Piper RC, Luzio JP.

Traffic. 2001 Sep;2(9):612-21. doi: 10.1034/j.1600-0854.2001.20904.x.

PMID: 11555415 Review.

 

Relationship between endosomes and lysosomes.

Luzio JP, Mullock BM, Pryor PR, Lindsay MR, James DE, Piper RC.

Biochem Soc Trans. 2001 Aug;29(Pt 4):476-80. doi: 10.1042/bst0290476.

PMID: 11498012 Review.

 

Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells.

Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE.

J Biol Chem. 2001 Jun 8;276(23):19820-7. doi: 10.1074/jbc.M010838200. Epub 2001 Mar 1.

PMID: 11278762

 

Syntaxin 7 is localized to late endosome compartments, associates with Vamp 8, and Is required for late endosome-lysosome fusion.

Mullock BM, Smith CW, Ihrke G, Bright NA, Lindsay M, Parkinson EJ, Brooks DA, Parton RG, James DE, Luzio JP, Piper RC.

Mol Biol Cell. 2000 Sep;11(9):3137-53. doi: 10.1091/mbc.11.9.3137.

PMID: 10982406 Free PMC article.

 

Lysosome-endosome fusion and lysosome biogenesis.

Luzio JP, Rous BA, Bright NA, Pryor PR, Mullock BM, Piper RC.

J Cell Sci. 2000 May;113 ( Pt 9):1515-24. doi: 10.1242/jcs.113.9.1515.

PMID: 10751143 Review.

 

The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane.

Urbanowski JL, Piper RC.

J Biol Chem. 1999 Dec 31;274(53):38061-70. doi: 10.1074/jbc.274.53.38061.

PMID: 10608875

 

Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.

Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE, Hunsaker LA, Piper RC, Makler MT, Vander Jagt DL.

J Med Chem. 1998 Sep 24;41(20):3879-87. doi: 10.1021/jm980334n.

PMID: 9748363